CADM1 CONTROLS ACTIN CYTOSKELETON ASSEMBLY AND REGULATES EXTRACELLULAR MATRIX ADHESION IN HUMAN MAST CELLS.

CADM1 is a major receptor for the adhesion of mast cells (MCs) to fibroblasts, human airway smooth muscle cells (HASMCs) and neurons.It also regulates E-cadherin and alpha6beta4 integrin in other cell types.Here we investigated a role for CADM1 in MC adhesion to both cells and extracellular matrix (ECM).Downregulation of CADM1 in the human MC line

As an important weather extreme, gales greatly impact the air quality, agriculture, aviation, and renewable energy in North China.However, the spatial–temporal changes in gale events remain unknown in North China.In this study, using the ERA5 reanalysis with high spatiotemporal resolution and multi-model simulations from the Coupled Model Interco